Thermodynamic and NMR analysis of inhibitor binding to dihydrofolate reductase

December 15, 2010

Authors: Batruch I, Javasky E, Brown ED, Organ MG, Johnson PE.
Reference: Bioorg Med Chem. 2010 Dec 15;18(24):8485-92. doi: 10.1016/j.bmc.2010.10.048. Epub 2010 Oct 26.

Chemical probes of Escherichia coli uncovered through chemical-chemical interaction profiling with compounds of known biological activity

August 27, 2010

Authors: Farha MA, Brown ED.
Reference: Chem Biol. 2010 Aug 27;17(8):852-62. doi: 10.1016/j.chembiol.2010.06.008.

Using a riboswitch sensor to examine coenzyme B(12) metabolism and transport in E. coli

July 30, 2010

Authors: Fowler CC, Brown ED, Li Y.
Reference: Chem Biol. 2010 Jul 30;17(7):756-65. doi: 10.1016/j.chembiol.2010.05.025.

An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase.

July 1, 2010

Authors: Orlicky S, Tang X, Neduva V, Elowe N, Brown ED, Sicheri F, Tyers M.
Reference: Nat Biotechnol. 2010 Jul;28(7):733-7. doi: 10.1038/nbt.1646. Epub 2010 Jun 27.

Chemical genomic approaches to study model microbes

June 25, 2010

Authors: Barker CA, Farha MA, Brown ED.
Reference: Chem Biol. 2010 Jun 25;17(6):624-32. doi: 10.1016/j.chembiol.2010.05.010. Review.

A high-throughput pharmacoviral approach identifies novel oncolytic virus sensitizers

June 1, 2010

Authors: Diallo JS, Le Boeuf F, Lai F, Cox J, Vaha-Koskela M, Abdelbary H, MacTavish H, Waite K, Falls T, Wang J, Brown R, Blanchard JE, Brown ED, Kirn DH, Hiscott J, Atkins H, Lichty BD, Bell JC.
Reference: Mol Ther. 2010 Jun;18(6):1123-9. doi: 10.1038/mt.2010.67. Epub 2010 Apr 13.

Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis

May 1, 2010

Authors: Lovering AL, Lin LY, Sewell EW, Spreter T, Brown ED, Strynadka NC.
Reference: Nat Struct Mol Biol. 2010 May;17(5):582-9. doi: 10.1038/nsmb.1819. Epub 2010 Apr 18.

Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting

November 1, 2009

Authors: Pathania R, Zlitni S, Barker C, Das R, Gerritsma DA, Lebert J, Awuah E, Melacini G, Capretta FA, Brown ED.
Reference: Nat Chem Biol. 2009 Nov;5(11):849-56. doi: 10.1038/nchembio.221. Epub 2009 Sep 27.

New screens and targets in antibacterial drug discovery

October 1, 2009

Authors: Falconer SB, Brown ED.
Reference: Curr Opin Microbiol. 2009 Oct;12(5):497-504. doi: 10.1016/j.mib.2009.07.001. Epub 2009 Aug 3. Review

Are essential genes really essential?

October 1, 2009

Authors: D'Elia MA, Pereira MP, Brown ED.
Reference: Trends Microbiol. 2009 Oct;17(10):433-8. doi: 10.1016/j.tim.2009.08.005. Epub 2009 Sep 16.

The wall teichoic acid polymerase TagF is non-processive in vitro and amenable to study using steady state kinetic analysis

August 7, 2009

Authors: Sewell EW, Pereira MP, Brown ED.
Reference: J Biol Chem. 2009 Aug 7;284(32):21132-8. doi: 10.1074/jbc.M109.010215. Epub 2009 Jun 11.

High-throughput screening identifies novel inhibitors of the acetyltransferase activity of Escherichia coli GlmU

June 1, 2009

Authors: Pereira MP, Blanchard JE, Murphy C, Roderick SL, Brown ED.
Reference: Antimicrob Agents Chemother. 2009 Jun;53(6):2306-11. doi: 10.1128/AAC.01572-08. Epub 2009 Apr 6.

The N-acetylmannosamine transferase catalyzes the first committed step of teichoic acid assembly in Bacillus subtilis and Staphylococcus aureus

June 1, 2009

Authors: D'Elia MA, Henderson JA, Beveridge TJ, Heinrichs DE, Brown ED.
Reference: J Bacteriol. 2009 Jun;191(12):4030-4. doi: 10.1128/JB.00611-08. Epub 2009 Apr 17.

Probing teichoic acid genetics with bioactive molecules reveals new interactions among diverse processes in bacterial cell wall biogenesis

May 29, 2009

Authors: D'Elia MA, Millar KE, Bhavsar AP, Tomljenovic AM, Hutter B, Schaab C, Moreno-Hagelsieb G, Brown ED.
Reference: Chem Biol. 2009 May 29;16(5):548-56. doi: 10.1016/j.chembiol.2009.04.009.

High-throughput screening of model bacteria

March 13, 2009

Authors: Zlitni S, Blanchard JE, Brown ED.
Reference: Methods Mol Biol. 2009;486:13-27. doi: 10.1007/978-1-60327-545-3_2.

Drug discovery: Not as fab as we thought

March 5, 2009

Authors: Zlitni S, Brown ED.
Reference: Nature. 2009 Mar 5;458(7234):39-40. doi: 10.1038/458039a

The ATPase activity of an 'essential' Bacillus subtilis enzyme, YdiB, is required for its cellular function and is modulated by oligomerization

March 1, 2009

Authors: Karst JC, Foucher AE, Campbell TL, Di Guilmi AM, Stroebel D, Mangat CS, Brown ED, Jault JM
Reference: Microbiology. 2009 Mar;155(Pt 3):944-56. doi: 10.1099/mic.0.021543-0.

Identification of a toxic peptide through bidirectional expression of small RNAs

January 26, 2009

Authors: Mok WW, Navani NK, Barker C, Sawchyn BL, Gu J, Pathania R, Zhu RD, Brown ED, Li Y.
Reference: Chembiochem. 2009 Jan 26;10(2):238-41. doi: 10.1002/cbic.200800591.

Ribosome biogenesis; the KsgA protein throws a methyl-mediated switch in ribosome assembly.

December 7, 2008

Authors: Mangat CS, Brown ED.
Reference: Mol Microbiol. 2008 Dec;70(5):1051-3.

Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry.

November 3, 2008

Authors: Tropak MB, Kornhaber GJ, Rigat BA, Maegawa GH, Buttner JD, Blanchard JE, Murphy C, Tuske SJ, Coales SJ, Hamuro Y, Brown ED, Mahuran DJ.
Reference: Chembiochem. 2008 Nov 3;9(16):2650-62. doi: 10.1002/cbic.200800304.

Publications