Isolation of DNA aptamers for CDP-ribitol synthase, and characterization of their inhibitory and structural properties.

Abstract:

Two birds with one stone: Four DNA aptamers were isolated for Bcs1, a bifunctional enzyme that catalyzes both the reduction of ribulose 5-phosphate by using NADPH and cytidylyltransfer by using CTP. The inhibitory effects of these aptamers towards Bcs1 and their secondary structural properties were investigated (see scheme).

Authors:

Allali-Hassani A, Pereira MP, Navani NK, Brown ED, Li Y.

Reference: 

Chembiochem. 2007 Nov 23;8(17):2052-7.