The wall teichoic acid polymerase TagF efficiently synthesizes poly(glycerol phosphate) on the TagB product lipid III.

Abstract: 

One piece at a time: Glycerol phosphate polymerization by the TagF enzyme is investigated through the use of a synthetic analogue of a teichoic acid intermediate. Analysis of polymerization products and reaction kinetics of the enzyme suggest a distributive assembly of the teichoic acid polymer on the TagB product lipid III.

Authors:

Pereira MP, Schertzer JW, D'Elia MA, Koteva KP, Hughes DW, Wright GD, Brown ED.

Reference:

Chembiochem. 2008 Jun 16;9(9):1385-90. doi: 10.1002/cbic.200800026